Evaluation of the in vivo anti-inflammatory activity of a flavonoid glycoside from Boldoa purpurascens

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• 作者：Dulce Maria  ; Gonzá ; lez Mosquera^a ; Yannarys Hernandez  ; Ortega^a ; Amuri  ; Kilonda^b ; Wim  ; Dehaen^b ; Luc  ; Pieters^c ;   ; ^{luc.pieters@ua.ac.be} ; Sandra  ; Apers^c
• 关键词：Boldoa purpurascens Cav. ; Nyctaginaceae ; Flavonol glycoside ; In vivo anti-inflammatory activity
• 刊名：Phytochemistry Letters
• 出版年：2011
• 出版时间：September 2011
• 年：2011
• 卷：4
• 期：3
• 页码：231-234
• 全文大小：237 K

文摘

The anti-inflammatory effect of 4?5-dihydroxy-6,7-methylenedioxyflavonol 3-O-¦Á-l-rhamnopyranosyl-(1 ?2)-¦Â-d-xylopyranoside, a constituent of the leaves of Boldoa purpurascens Cav. (Nyctaginaceae), was evaluated for its anti-inflammatory activity in the dextran 1 % induced rat paw oedema model (acute inflammation) and the cotton pellet induced granuloma rat model (chronic inflammation). Flavonoid glycoside at doses of 2.5, 5 and 10 mg/kg, indomethacin at a dose of 7 mg/kg and the vehicle were administered orally. The compound showed significant anti-inflammatory activity in the acute phase in a dose dependent manner, most notably at the highest test dose 10 mg/kg. Also in the cotton pellet induced granuloma model, the compound showed a dose-dependent anti-inflammatory activity, with the highest effect at 10 mg/kg. In both assays, the test compound was more active than indomethacin tested at 7 mg/kg.