Antiplasmodial and cytotoxic activities of Striga asiatica and Sauropus spatulifolius extracts, and their isolated constituents

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• 作者：Ying-Shu Zou^a ; Kenn Foubert^a ; Emmy Tuenter^a ; Filip Lemiè ; re^b ; Paul Cos^c ; Louis Maes^c ; Jan M.M. Smits^d ; René ; de Gelder^d ; Sandra Apers^a ; Luc Pieters^a ; ^{luc.pieters@ua.ac.be}
• 关键词：Striga asiatica ; Sauropus spatulifolius ; N-Hydroxyethyl-2-acetylpyrrole ; N-(3-Carboxypropyl)-2-acetylpyrrole ; Sauropic acid ; Plasmodium falciparum
• 刊名：Phytochemistry Letters
• 出版年：2013
• 出版时间：February, 2013
• 年：2013
• 卷：6
• 期：1
• 页码：53-58
• 全文大小：352 K

文摘

A phytochemical investigation of Striga asiatica and the leaves of Sauropus spatulifolius revealed seventeen compounds, three of which were reported for the first time from nature, i.e. two alkaloids N-hydroxyethyl-2-acetylpyrrole, N-(3-carboxypropyl)-2-acetylpyrrole, and 2-(4-hydroxy-2,2,6-trimethylcyclohexyl)acetic acid, for which the name sauropic acid was adopted. Their structures were established spectroscopically and by single-crystal X-ray diffraction analysis. All extracts and isolates were evaluated for antiplasmodial activity against Plasmodium falciparum strain K1 and for cytotoxicity against MRC-5 cells.