Different routes and doses influence protection in pigs immunised with the naturally attenuated African swine fever virus isolate OURT88/3

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• 作者：Pedro J. Sá ; nchez-Cordó ; n ; ¹ ; ^{pedro.sanchez-cordon@pirbright.ac.uk} ; Dave Chapman¹ ; Tamara Jabbar ; Ana L. Reis ; Lynnette Goatley ; Christopher L. Netherton ; Geraldine Taylor ; Maria Montoya ; Linda Dixon
• 关键词：African swine fever ; Pigs ; Immunisation routes ; Protection ; Cytokines
• 刊名：Antiviral Research
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：138
• 期：Complete
• 页码：1-8
• 全文大小：2590 K
• 卷排序：138

文摘

Protection induced by combinations of doses and routes of immunisation of pigs with ASFV isolate OUR T88/3 is described. Intranasal immunisations with low and moderate doses provided complete protection with persistent low virus genome levels. Intramuscular immunisations with low and moderate doses provided lower protection with undetectable virus genome levels. Increased IL-10 serum concentrations, sometimes together with increased IFNγ, was observed before death in not-protected pigs. Changes in serum concentrations of TNFα, IFNγ, IL-4 and IL-10 were not detected in none of immunised protected pigs.