Wide therapeutic time-window of low-frequency stimulation at the subiculum for temporal lobe epilepsy treatment in rats
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- 作者：Kai Zhong ; Deng-Chang Wu ; Miao-Miao Jin ; Zheng-Hao Xu ; Yi Wang ; Wei-Wei Hou ; Xiao-Ming Li ; Shi-Hong Zhang ; Zhong Chen
- 关键词：LFS ; low-frequency stimulation ; DBS ; deep brain stimulation ; HFS ; high-frequency stimulation ; AD ; afterdischarge ; TLE ; temporal lobe epilepsy ; EEG ; electroencephalogram ; ADT ; afterdischarge threshold ; ADD ; afterdischarge duration ; GS ; generalized seizure
- 刊名：Neurobiology of Disease
- 出版年：2012
- 出版时间：October, 2012
- 年：2012
- 卷：48
- 期：1
- 页码：20-26
- 全文大小：1046 K
文摘
Low-frequency stimulation (LFS) has been considered as an option for the treatment of intractable epilepsy. However, previous data showed that LFS of certain brain regions only exerts its effect within a very narrow therapeutic time window, which lasts from seconds to tens of seconds, thus restricting its clinical application. The present study was designed to determine whether there exists a target with a wider therapeutic window for LFS treatment. Therefore, evoked seizures in the rat were induced by amygdala kindling and spontaneous seizures were induced by pilocarpine. The effects of different modes of LFS at the subiculum on the progression and severity of evoked seizures and the frequency of spontaneous seizure were evaluated. We found that (i) LFS at 1 Hz delivered to the subiculum before and immediately after the kindling stimulations, or after the cessation of afterdischarge (afterdischarge duration, ADD) decreased the seizure stages and shortened the ADD both in seizure acquisition and expression in amygdaloid-kindled seizures. In addition, even LFS delivered after duration of double the ADD prolonged the kindling progression. (ii) LFS delivered at 1 Hz, but not 0.5, 3 or 130 Hz, immediately after the cessation of kindling stimulations retarded the progression of kindling seizures. (iii) Pilocarpine-induced spontaneous seizures were completely inhibited by 1 Hz LFS. Thus, these results demonstrated that LFS of the subiculum has a wide therapeutic time-window for temporal lobe epilepsy treatment in rats, suggesting that the subiculum may be a promising and suitable target for clinical application.