Sesquiterpenes from the rhizome of Curcuma longa with inhibitory activity on superoxide generation and elastase release by neutrophils

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• 作者：Jih-Jung Chen ; Cheng-Shuan Tsai ; Tsong-Long Hwang ; Po-Chuen Shieh ; Jinn-Fen Chen ; Ping-Jyun Sung
• 关键词：Curcuma longa ; Zingiberaceae ; Structure elucidation ; Sesquiterpenes ; Inhibitory activity on neutrophil pro-inflammatory responses
• 刊名：Food Chemistry
• 出版年：2010
• 出版时间：1 April 2010
• 年：2010
• 卷：119
• 期：3
• 页码：974-980
• 全文大小：355 K

文摘

Six new sesquiterpenes, curculonone A (1), curculonone B (2), curculonone C (3), curculonone D (4), 6α-hydroxycurcumanolide A (5), and 1,10-dehydro-10-deoxy-9-oxozedoarondiol (6), have been isolated from the rhizome of Curcuma longa, together with 19 known compounds. The structures of these new compounds were determined through spectroscopic and MS analyses. Compounds 1, 2, 5, 12, 15, 16, and 23 exhibited inhibition (IC₅₀  18.22 μM) of superoxide anion generation by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB). Compounds 5, 12–16, and 23 inhibited fMLP/CB-induced elastase release with IC₅₀ values  14.28 μM.