Hepatoprotective effects of eburicoic acid and dehydroeburicoic acid from Antrodia camphorata in a mouse model of acute hepatic injury

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• 作者：Guan-Jhong Huang ; Jeng-Shyan Deng ; Shyh-Shyun Huang ; Chao-Ying Lee ; Wen-Chi Hou ; Sheng-Yang Wang ; Ping-Jyun Sung ; Yueh-Hsiung Kuo
• 关键词：Antrodia camphorata ; Eburicoic acid ; Dehydroeburicoic acid ; Anti-inflammation ; NO ; TNF-¦Á
• 刊名：Food Chemistry
• 出版年：2013
• 出版时间：1 December, 2013
• 年：2013
• 卷：141
• 期：3
• 页码：3020-3027
• 全文大小：1150 K

文摘

The hepatoprotective effects of eburicoic acid (TR1) and dehydroeburicoic acid (TR2) from Antrodia camphorata (AC) against carbon tetrachloride (CCl₄)-induced liver damage were investigated in mice. TR1 and TR2 was administered intraperitoneally (i.p.) for 7 days prior to the administration of CCl₄. Pretreatment with TR1 and TR2 prevented the elevation of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and liver lipid peroxides in CCl₄-treated mice. The activities of antioxidant enzymes [catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx)], nitric oxide (NO) production, and tumour necrosis factor-alpha (TNF-¦Á) were decreased after the treatment with TR1 and TR2 in CCl₄-treated mice. Western blotting revealed that TR1 and TR2 significantly decreased inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expressions and increased the expression of cytochrome P4502E1 (CYP2E1) in CCl₄-treated mice. Therefore, we speculate that TR1 and TR2 protect the liver from CCl₄-induced hepatic damage via antioxidant and anti-inflammatory mechanisms.