Studies on the interaction between promethazine and human serum albumin in the presence of flavonoids by spectroscopic and molecular modeling techniques
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- 作者：Ling-Ling Hea ; 1 ; Zhi-Xin Wanga ; 1 ; Yong-Xia Wanga ; 1 ; Xian-Ping Liua ; Yan-Jie Yanga ; Yan-Ping Gaoa ; Xin Wangb ; Bin Liub ; liubinzehao@163.com" class="auth_mail" title="E-mail the corresponding author ; Xin Wang ; b ; xin_wang@lnu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Flavonoids ; Promethazine ; Human serum albumin ; Competitive binding ; Food-drug interaction
- 刊名：Colloids and Surfaces B: Biointerfaces
- 出版年：2016
- 出版时间：1 September 2016
- 年：2016
- 卷：145
- 期：Complete
- 页码：820-829
- 全文大小：1833 K
文摘
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The binding characterizations of PMT binding to HSA were investigated.
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The influences of flavonoids on HSA–PMT interaction were investigated.
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The fluorescence, absorption, CD spectra and molecular modeling were used.
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This work may be helpful to illustrate food-drugs interactions.