Four new diterpenoid alkaloids with antitumor effect from Aconitum nagarum var. heterotrichum

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• 作者：Da-Ke Zhao^a ; Xing-Qiao Shi^a ; Li-Mei Zhang^b ; Dong-Qiong Yang^c ; Hua-Chun Guo^b ; ^{ynghc@126.com} ; Yan-Ping Chen^b ; Yong Shen^b ; ^{pharmsy@sina.com}
• 关键词：Ranunculaceae ; Aconitum nagarum var. heterotrichum ; Diterpenoid alkaloids ; Nagaconitines A-D ; Antitumor activity
• 刊名：Chinese Chemical Letters
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：28
• 期：2
• 页码：358-361
• 全文大小：493 K
• 卷排序：28

文摘

Four new diterpenoid alkaloids, nagaconitines A-D (1–4), were isolated from the roots of Aconitum nagarum var. heterotrichum. Their structures were elucidated as 8-(4′-hydroxylbutyryl) aconitine (1), 15-oxo-13-deoxyludaconitine (2), 15-hydroxyldelphisine (3), and 14-hydroxyl-2- acetoxyspiradine C (4) based on extensive UV, IR, MS, 1D NMR and 2D NMR analyses. Compounds 3-4 showed inhibition of cancer cell line SK-OV-3 with 31% (IC50 43.78 μmol/L) and 24% (IC50 32.14 μmol/L), respectively.