Aldehyde dehydrogenases and cancer stem cells
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- 作者：Xia Xu1 ; Shoujie Chai1 ; Pingli Wang ; Chenchen Zhang ; Yiming Yang ; Ying Yang ; Kai Wang ; kaiw@zju.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Aldehyde dehydrogenase ; Cancer stem cell ; Metabolic substrate ; Signal transduction
- 刊名：Cancer Letters
- 出版年：2015
- 出版时间：1 December 2015
- 年：2015
- 卷：369
- 期：1
- 页码：50-57
- 全文大小：1161 K
文摘
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Aldehyde dehydrogenase (ALDH) is cancer prognostic marker and plays as marker of cancer stem cells (CSCs).
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ALDH takes part in retinoic acid-mediated signalling, reducing active oxygen species and resisting drug toxicity.
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ALDH is regulated by RA, Notch, Wnt or TGF-β pathways in CSCs.