An efficient method to synthesize novel 5-O-(6′-modified)-mycaminose 14-membered ketolides

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• 作者：A-Peng Wang ; Chao Liu ; Shuang Yang ; Zhehui Zhao ; ^{zhaozh@imm.ac.cn" class="auth_mail" title="E-mail the corresponding author} ; Pingsheng Lei ; ^&dagger ; ; ^{leips@imm.ac.cn" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Ketolides ; Desosamine mimetics ; Mycaminose ; Glycosylation ; Modification
• 刊名：Tetrahedron
• 出版年：2016
• 出版时间：14 January 2016
• 年：2016
• 卷：72
• 期：2
• 页码：285-297
• 全文大小：1040 K

文摘

A new and facile procedure was developed to synthesize novel 5-O-(6′-modified)-mycaminose 14-membered ketolides by adopting different protective strategies and comparing various glycosylation conditions. Seven trichloroacetimidate donors which had different types of substituent groups at C-6 position were synthesized to couple with the erythronolide. Nine novel 5-O-(6′-modified)-mycaminose 14-membered ketolides were obtained to verify the utility of the method.