Synthesis and antibacterial activity of novel modified 5-O-mycaminose 14-membered ketolides
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- 作者：Yanpeng Xu ; Xiaozhuo Chen ; Di Zhu ; Yi Liu ; Zhehui Zhao ; Longlong Jin ; Chao Liu ; Pingsheng Lei
- 关键词：14-Membered ketolide ; Desosamine ; Mycaminose ; Synthesis ; Antibacterial activity
- 刊名：European Journal of Medicinal Chemistry
- 出版年：November, 2013
- 年：2013
- 卷：69
- 期：Complete
- 页码：174-181
- 全文大小：789 K
文摘
A practicable method of introducing a side chain to the C-4鈥?position of 5-O-desosamine in the 14-membered ketolides was developed. And using this method, a series of novel modified 5-O-mycaminose ketolides were synthesized. These ketolides containing 5-O-4鈥?carbamate mycaminose were evaluated for their in聽vitro antibacterial activities against some respiratory pathogens. 15b and 18e showed comparable activity to telithromycin and clarithromycin.