Kinetics and molecular docking studies of fucosterol and fucoxanthin, BACE1 inhibitors from brown algae Undaria pinnatifida and Ecklonia stolonifera
详细信息 查看全文
- 作者：Hyun Ah Junga ; 1 ; Md Yousof Alib ; 1 ; Ran Joo Choic ; Hyong Oh Jeongd ; Hae Young Chungd ; Jae Sue Choib ; choijs@pknu.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：BACE1 ; Alzheimer's disease ; Docking analysis ; Enzyme kinetic ; Fucosterol ; Fucoxanthin
- 刊名：Food and Chemical Toxicology
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：89
- 期：Complete
- 页码：104-111
- 全文大小：1294 K
文摘
- •
Enzyme kinetic and docking simulation studies were simultaneously performed.
- •
Fucosterol showed noncompetitive inhibition against BACE1 enzyme.
- •
Fucoxanthin showed mixed-type inhibition against BACE1 enzyme.
- •
Amino acid residues on BACE1 interacted with functional groups of two compounds.
- •
Two compounds as BACE1 inhibitors may be used in the treatment of AD.