Impaired mutagenic activities of MPDP⁺ (1-methyl-4-phenyl-2,3-dihydropyridinium) and MPP⁺ (1-methyl-4-phenylpyridinium) due to their interactions with methylxanthines

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• 作者：Katarzyna Ulanowska ; Jacek Piosik ; Anna Gwizdek-Wiś ; niewska ; Grzegorz Wę ; grzyn
• 关键词：Parkinson’ ; s disease ; Stacking complexes ; Mutagenicity ; MPDP⁺ (1-methyl-4-phenyl-2 ; 3-dihydropyridinium) ; MPP⁺ (1-methyl-4-phenylpyridinium) ; Methylxanthines
• 刊名：Bioorganic and Medicinal Chemistry
• 出版年：2007
• 出版时间：1 August 2007
• 年：2007
• 卷：15
• 期：15
• 页码：5150-5157
• 全文大小：584 K

文摘

MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) is a neurotoxin causing symptoms that resemble those observed in patients suffering from Parkinson’s disease. However, in animal or human organisms, MPTP is converted to MPDP⁺ (1-methyl-4-phenyl-2,3-dihydropyridinium) and further to MPP⁺ (1-methyl-4-phenylpyridinium); the latter compound is the actual neurotoxin. In this report, we demonstrate that MPDP⁺ and MPP⁺ can form stacking complexes with methylxanthines (caffeine and penthoxifylline), which leads to significant impairment of the biological activity of these toxins (as measured by their mutagenicity).