Patients with documented PVCs between January 2001 and October 2012 were divided into 2 groups: MVP and non-MVP. The PVC characteristics, efficacy of therapy, and outcome were compared between the 2 groups. A total of 112 patients with MVP and 952 without MVP were identified. The frequency of PVCs was similar between the 2 groups (P > .05). In patients who underwent cardiac mapping, PVCs originating in papillary muscles (26.7% vs 2.3%; P < .001) and fascicle (13.3% vs 3.4%; P < .001) were more frequently seen in the MVP group than in the non-MVP group, which raises the difficulty of catheter ablation. The 2 groups had similar response to catheter ablation or medical therapy (P > .05). The survival rate was similar between the 2 groups (P = .95).
In patients with significant PVC burden, MVP patients had similar PVC frequency, treatment outcome, and survival rate to those without MVP.