Multiple, independent, identical IS6110 insertions in Mycobacterium tuberculosis PPE genes

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• 作者：Christopher R.E. McEvoy ; Robin M. Warren ; Paul D. van Helden ; Nicolaas C. Gey van Pittius
• 关键词：IS6110 ; PPE ; Transposable elements ; IS6110 insertion sequence ; PPE family
• 刊名：Tuberculosis
• 出版年：2009
• 出版时间：November 2009
• 年：2009
• 卷：89
• 期：6
• 页码：439-442
• 全文大小：260 K

文摘

Summary

IS6110 is a transposable element found in Mycobacterium tuberculosis complex members. Regions of preferential IS6110 integration occur within the M. tuberculosis genome but the element has not previously been shown to exhibit any sequence-specific integration preferences. Here we provide evidence for multiple independent IS6110 insertions into identical, or near-identical, positions within the highly homologous 5′ region of 3 PPE genes.