The effects of normal aging on amyloid-β deposition in nondemented adults with Down syndrome as imaged by carbon 11-labeled Pittsburgh compound B

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• 作者：Patrick J. Lao^a ; ^b ; Tobey J. Betthauser^a ; ^b ; Ansel T. Hillmer^a ; ^b ; Julie C. Price^c ; William E. Klunk^d ; Iulia Mihaila^b ; Andrew T. Higgins^b ; Peter D. Bulova^c ; Sigan L. Hartley^b ; Regina Hardison^e ; Rameshwari V. Tumuluru^d ; Dhanabalan Murali^a ; ^b ; Chester A. Mathis^f ; Annie D. Cohen^d ; Todd E. Barnhart^a ; Darlynne A. Devenny^g ; Marsha R. Mailick^b ; Sterling C. Johnson^h ; Benjamin L. Handen^d ; Bradley T. Christian^a ; ^b ; ⁱ ; ^{bchristian@wisc.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Down syndrome ; Alzheimer's disease ; Amyloid imaging ; PiB ; Aging
• 刊名：Alzheimer's & Dementia
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：12
• 期：4
• 页码：380-390
• 全文大小：1547 K

文摘

In Down syndrome (DS), the overproduction of amyloid precursor protein is hypothesized to predispose young adults to early expression of Alzheimer-like neuropathology.

Methods

PET imaging with carbon 11–labeled Pittsburgh compound B examined the pattern of amyloid-β deposition in 68 nondemented adults with DS (30–53 years) to determine the relationship between deposition and normal aging. Standard uptake value ratio (SUVR) images were created with cerebellar gray matter as the reference region.

Results

Multiple linear regression revealed slight but highly significant (corrected P < .05) positive correlations between SUVR and age. The striatum showed the strongest correlation, followed by precuneus, parietal cortex, anterior cingulate, frontal cortex, and temporal cortex.

Conclusion

There is an age-related amyloid-β deposition in the DS population, but as a pattern of elevated cortical retention becomes apparent, the correlation of SUVR with age ceases to be significant. Factors unrelated to aging may drive an increase in deposition during early Alzheimer's disease pathogenesis.