Circulating levels of p,p'-DDE are related to prevalent hypertension in the elderly

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• 作者：P. Monica Lind ; Johanna Penell ; Samira Salihovic ; Bert van Bavel ; Lars Lind
• 关键词：AHR ; aryl hydrocarbon receptor ; BDE ; brominated biphenyl ether ; CI ; confidence interval ; p ; p'-DDE ; 1 ; 1-dichloro-2 ; 2-bis(4-dichlordiphenyl) ethylene ; a metabolite to DDT ; DDT ; dichlorodiphenyltrichlorethane ; ET-1 ; endothelin-1 ; HCB ; hexachlorobenzene ; HRGC ; high-resolution gas chromatography ; HRMS ; high-resolution mass spectrometry ; OC ; organochlorine ; OCDD ; octachlorodibenzo-p-dioxin ; PCBs ; polychlorinated biphenyls ; PIVUS ; Prospective Investigation of the Vasculature in Uppsala Seniors ; POPs ; p
• 刊名：Environmental Research
• 出版年：February, 2014
• 年：2014
• 卷：129
• 期：Complete
• 页码：27-31
• 全文大小：258 K

文摘

Background

Polychlorinated biphenyls (PCBs) and dioxin given to experimental animals increase the blood pressure. We therefore investigated if circulating levels of persistent organic pollutants (POPs) were related to hypertension in a population-based sample of men and women.

Methods

One thousand and sixteen subjects aged 70 years were investigated in the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study. Twenty-three POPs were analyzed using high-resolution gas chromatography/high-resolution mass spectrometry (HRGC/HRMS). Hypertension was defined as a systolic blood pressure 鈮?40 mmHg or a diastolic blood pressure 鈮?0 mmHg, and/or use of antihypertensive medication.

Results

Seven hundred and thirty-two subjects (72%) showed hypertension. When the POPs were treated as continuous variables and adjusted for gender only, two PCBs with a low number of chlorine atoms (PCB 105 and 118) were related to prevalent hypertension. Also the OC pesticide p,p'-DDE was related to hypertension. The strongest of these associations was seen for p,p'-DDE (OR 1.35 for a 1 SD change, 95% CI 1.17-1.56, p<0.0001). Following further adjustment also for BMI, smoking status, education level and exercise habits, only p,p'-DDE was still significantly related to hypertension (OR 1.23 for a 1 SD change, 95% CI 1.06-1.43, p=0.006).

Conclusion

In this cross-sectional analysis of an elderly population, high levels of circulating levels of p,p'-DDE were associated with prevalent hypertension, further strengthening the experimental findings that POPs might influence blood pressure.