Argonaute: The executor of small RNA function

详细信息    查看全文

• 作者：Azali Azlan^a ; Najat Dzaki^a ; Ghows Azzam^a ; ^b ; ^{ghows@usm.my" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Argonaute ; Small RNAs ; RNAi ; Drosophila melanogaster ; Human ; Model organisms ; Gene silencing
• 刊名：Journal of Genetics and Genomics
• 出版年：2016
• 出版时间：20 August 2016
• 年：2016
• 卷：43
• 期：8
• 页码：481-494
• 全文大小：1407 K

文摘

The discovery of small non-coding RNAs – microRNA (miRNA), short interfering RNA (siRNA) and PIWI-interacting RNA (piRNA) – represents one of the most exciting frontiers in biology specifically on the mechanism of gene regulation. In order to execute their functions, these small RNAs require physical interactions with their protein partners, the Argonaute (AGO) family proteins. Over the years, numerous studies have made tremendous progress on understanding the roles of AGO in gene silencing in various organisms. In this review, we summarize recent progress of AGO-mediated gene silencing and other cellular processes in which AGO proteins have been implicated with a particular focus on progress made in flies, humans and other model organisms as compliment.