Development of bone-like zirconium oxide nanoceramic modified chitosan based porous nanocomposites for biomedical application

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• 作者：Arundhati Bhowmick^a ; Nilkamal Pramanik^a ; Piyali Jana^a ; Tapas Mitra^a ; Arumugam Gnanamani^b ; Manas Das^c ; Patit Paban Kundu^a ; ^d ; ^{ppk923@yahoo.com}
• 关键词：Zirconium oxide ; Chitosan ; Poly(ethylene glycol) ; Hydroxyapatite ; Nanocomposites
• 刊名：International Journal of Biological Macromolecules
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：95
• 期：Complete
• 页码：348-356
• 全文大小：1354 K
• 卷排序：95

文摘

Here, zirconium oxide nanoparticles (ZrO2 NPs) were incorporated for the first time in organic-inorganic hybrid composites containing chitosan, poly(ethylene glycol) and nano-hydroxypatite (CS-PEG-HA) to develop bone-like nanocomposites for bone tissue engineering application. These nanocomposites were characterized by FT-IR, XRD, TEM combined with SAED. SEM images and porosity measurements revealed highly porous structure having pore size of less than 1 μm to 10 μm. Enhanced water absorption capacity and mechanical strengths were obtained compared to previously reported CS-PEG-HA composite after addition of 0.1–0.3 wt% of ZrO2 NPs into these nanocomposites. The mechanical strengths and porosities were similar to that of human spongy bone. Strong antimicrobial effects against gram-negative and gram-positive bacterial strains were also observed. Along with getting low alkalinity pH (7.4) values, similar to the pH of human plasma, hemocompatibility and cytocompatibility with osteoblastic MG-63 cells were also established for these nanocomposites. Addition of 15 wt% HA-ZrO2 (having 0.3 wt% ZrO2 NPs) into CS-PEG (55:30 wt%) composite resulted in greatest mechanical strength, porosity, antimicrobial property and cytocompatibility along with suitable water absorption capacity and compatibility with human pH and blood. Thus, this nanocomposite could serve as a potential candidate to be used for bone tissue engineering.