Downregulation of miR-29a/b/c in placenta accreta inhibits apoptosis of implantation site intermediate trophoblast cells by targeting MCL1
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- 作者：Yongzhong Gua ; Yuehong Bianb ; c ; d ; Xiaofei Xub ; c ; d ; Xietong Wanga ; Changting Zuoa ; Jinlai Menga ; Hongyan Lia ; Shigang Zhaob ; c ; d ; Yunnan Ningb ; c ; d ; Yongzhi Caob ; c ; d ; Tao Huangb ; c ; d ; Junhao Yana ; b ; c ; d ; yyy306@126.com" class="auth_mail" title="E-mail the corresponding author ; Zi-Jiang Chena ; b ; c ; d ; e ; f ; chenzijiang@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Placenta accreta ; microRNA-29a/b/c ; MCL1 ; Intermediate trophoblast ; Apoptosis
- 刊名：Placenta
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：48
- 期：Complete
- 页码：13-19
- 全文大小：1577 K
文摘
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Expression of miR-29a/b/c was lower in placenta accreta tissues.
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MCL1 is a target gene of miR-29a/b/c.
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MCL1 is upregulated in implantation site intermediate trophoblast cells from placenta accreta samples.
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In placenta accreta, miR-29a/b/c inhibits apoptosis of implantation site intermediate trophoblast cells by targeting MCL1.