Localisation of epidermal growth factor (EGF), its specific receptor (EGF-R) and aromatase at the materno-fetal interface during placentation in the pregnant mare

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• 作者：W.R. Twink Allen ; ¹ ; ^{twinkallen100@gmail.com} ; Susan Gower ; Sandra Wilsher¹
• 关键词：Mare ; Trophoblast ; Endometrial glands ; EGF ; EGF-R ; Endometrial cups ; Oestrogens ; Progestagens
• 刊名：Placenta
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：50
• 期：Complete
• 页码：53-59
• 全文大小：3663 K
• 卷排序：50

文摘

In equine pregnancy EGF is secreted by the uterine gland epithelium. In equine pregnancy EGF-R is expressed on the surface of the trophoblast cells. Expression of EGF and EGF-R increases just prior to commencing placentation. Aromatase is expressed by trophoblast cells throughout equine pregnancy. Oestrogens likely synergise with EGF to stimulate placental development.