Regulation of structural and functional synapse density by L-threonate through modulation of intraneuronal magnesium concentration
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- 作者：Qifeng Suna ; Jason G. Weingerb ; Fei Maob ; Guosong Liua ; b ; gliu@neurocentria.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Threonate ; Synaptic density ; Functional terminals ; Intracellular Mg2+ ; Rat ; Human stem cell-derived neurons
- 刊名：Neuropharmacology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：108
- 期：Complete
- 页码：426-439
- 全文大小：3637 K
文摘
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Threonate concentrations in rat CSF is approximately 100 μM, approximately 5-fold higher than blood plasma concentrations.
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Oral treatment with L-TAMS selectively increases CNS threonate by 50%, with no peripheral accumulation of threonate.
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Threonate increases neuronal [Mg2+]i, and augments structural and functional synapse density.
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Threonate-induced increase of [Mg2+]i and downstream functional synapse density was specifically mediated through GLUTs.
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Threonate enhances the expression of Syn and PSD-95 in human neural stem cell-derived neurons.