Major changes in the sphingophospholipidome of HDL in non-diabetic patients with metabolic syndrome
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- 作者：Damien Denimala ; b ; Amandine Nguyenc ; Jean-Paul Pais de Barrosd ; Benjamin Bouilleta ; c ; Jean-Michel Petita ; c ; Bruno Vergè ; sa ; c ; Laurence Duvillarda ; b ; laurence.duvillard@chu-dijon.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：HDL ; Lipidomic ; Metabolic syndrome ; Phospholipids ; Sphingolipids ; Tandem mass spectrometry
- 刊名：Atherosclerosis
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：246
- 期：Complete
- 页码：106-114
- 全文大小：804 K
文摘
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In metabolic syndrome without diabetes the HDL2 and HDL3 sphingophospholipidome shows major changes.
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The proportion of sphingomyelins, plasmalogens and d18:1-sphingosine-1-phosphate is decreased.
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The proportion of lysophosphatidylcholines and phosphatidylinositols is increased.
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These changes could contribute to the impaired functionality of HDL in metabolic syndrome.
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C18:2 fatty acid-containing phospholipids are decreased and C20:4 fatty acid-containing ones are increased.