Decreased phosphatidylcholine plasmalogens - A putative novel lipid signature in patients with stable coronary artery disease and acute myocardial infarction
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- 作者：Iryna Suttera ; b ; 1 ; Roland Klingenbergc ; 1 ; Alaa Othmana ; e ; Lucia Rohrera ; Ulf Landmesserb ; c ; d ; Dierik Hege ; Nicolas Rodondif ; Francois Machg ; Stephan Windeckerh ; Christian M. Matterb ; c ; Thomas F. Lü ; scherb ; c ; Arnold von Eckardsteina ; b ; i ; Thorsten Hornemanna ; b ; i ; thorsten.hornemann@usz.ch" class="auth_mail" title="E-mail the corresponding author
- 关键词：Glycerophospholipids ; Sphingolipids ; Coronary artery disease ; Acute myocardial infarction
- 刊名：Atherosclerosis
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：246
- 期：Complete
- 页码：130-140
- 全文大小：1525 K
文摘
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Sixty five plasma glycerophospho- and sphingolipid species were quantified in patients with stable CAD or AMI and compared to healthy subjects.
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45 and 42 glycerophospholipid and sphingolipid species were significantly lower in the CAD and AMI group, respectively.
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Four PC plasmalogens (PC33:1, PC33:2, PC33:3 and PC35:3) showed the most significant difference and were associated with HDL.
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The observed differences were not explained by the use of statins as confirmed in a second, independent cohort.