A comprehensive lipidomic screen of pancreatic β-cells using mass spectroscopy defines novel features of glucose-stimulated turnover of neutral lipids, sphingolipids and plasmalogens
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- 作者：Gemma L. Pearson1 ; 2 ; 4 ; 5 ; Natalie Mellett3 ; 4 ; Kwan Yi Chu1 ; Ebru Boslem1 ; 2 ; Peter J. Meikle3 ; 6 ; peter.meikle@bakeridi.edu.au" class="auth_mail" title="E-mail the corresponding author ; Trevor J. Biden1 ; 2 ; 6 ; t.biden@garvan.org.au" class="auth_mail" title="E-mail the corresponding author
- 关键词：Pancreatic β-cell ; Insulin secretion ; Diacylglycerol ; Monacylglycerol ; Ceramide ; Plasmalogen
- 刊名：Molecular Metabolism
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：5
- 期：6
- 页码：404-414
- 全文大小：2127 K
文摘
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Using mass spectroscopy lipidomics we have defined new aspects of glucose simulated lipid turnover in pancreatic beta cells.
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Glucose directly stimulates triacylglycerol hydrolysis, of which di-saturated diacylglycerol species are excellent markers.
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C18:1 is the most abundant monacylglycerol, and the one most obviously increased by glucose.
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Phosphatidylcholine plasmalogens with poly-unsaturated side chains are preferentially decreased by glucose.
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Glucose specifically enhances the conversion of ceramide to both sphingomyelin and galactosylceramide.