The biophysical properties of ethanolamine plasmalogens revealed by atomistic molecular dynamics simulations
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- 作者：Tomasz Roga ; Artturi Koivuniemib ; artturi.koivuniemi@vtt.fi" class="auth_mail" title="E-mail the corresponding author
- 关键词：Lipid membrane ; Plasmalogens ; Neurodegenerative diseases ; Molecular dynamics
- 刊名：Biochimica et Biophysica Acta (BBA)-Biomembranes
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：1858
- 期：1
- 页码：97-103
- 全文大小：1009 K
文摘
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We studied the biophysical properties of a plasmalogen lipid bilayer utilizing atomistic molecular dynamics simulations
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We clarified the impact of vinyl-ether linkage of plasmalogens to the lipid bilayer properties
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The plasmalogen lipids form a more compressed and thicker lipid bilayer compared to the diacyl counterpart and POPC lipids.
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The vinyl-ether linkage packs the proximal regions of the acyl chains more closely together.