(S)Pot on Mitochondria: Cannabinoids Disrupt Cellular Respiration to Limit Neuronal Activity

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• 作者：Tibor Harkany¹ ; ² ; ^{tibor.harkany@meduniwien.ac.at} ; Tamas L. Horvath³
• 关键词：cannabinoid ; cannabis ; THC ; endocannabinoid ; cannabinoid receptor 1 ; mitochondrial import ; GPCR ; axonal growth ; respiration ; bioenergetics
• 刊名：Cell Metabolism
• 出版年：2017
• 出版时间：10 January 2017
• 年：2017
• 卷：25
• 期：1
• 页码：8-10
• 全文大小：452 K
• 卷排序：25

文摘

Classical views posit G protein-coupled cannabinoid receptor 1s (CB1Rs) at the cell surface with cytosolic Giα-mediated signal transduction. Hebert-Chatelain et al. (2016) instead place CB1Rs at mitochondria limiting neuronal respiration by soluble adenylyl cyclase-dependent modulation of complex I activity. Thus, neuronal bioenergetics link to synaptic plasticity and, globally, learning and memory.