Modulation of serotonergic transmission by eltoprazine in L-DOPA-induced dyskinesia: Behavioral, molecular, and synaptic mechanisms
详细信息 查看全文
- 作者：Veronica Ghiglieria ; b ; 1 ; Desiree Mineob ; 2 ; Anna Vannellib ; 2 ; Fabrizio Cacaceb ; Maria Mancinib ; Valentina Pendolinob ; Francesco Napolitanoc ; d ; Anna di Maioc ; Manuela Mellonee ; Jennifer Stanice ; Elisabetta Troncif ; Camino Fidalgof ; Roberto Stancampianof ; Manolo Cartaf ; Paolo Calabresib ; g ; Fabrizio Gardonie ; Alessandro Usielloc ; h ; Barbara Picconib ; b.picconi@hsantalucia.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：Serotonergic transmission ; Bidirectional synaptic plasticity ; Parkinson's disease animal models ; Levodopa treatment
- 刊名：Neurobiology of Disease
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：86
- 期：Complete
- 页码：140-153
- 全文大小：1896 K
文摘
- •
The serotonergic system has a relevant role in L-DOPA-induced dyskinesia induction.
- •
The 5-HT1 agonist, eltoprazine, reduces dyskinesia and restores striatal bidirectional synaptic plasticity.
- •
Eltoprazine normalizes D1R-dependent cAMP/PKA and ERK/mTORC signaling pathways.
- •
L-DOPA and eltoprazine-treated parkinsonian rats show altered striatal learning behavior.
- •
The locomotor defect of parkinsonian and L-DOPA-treated rats is reversed by the treatment.