Signals from the Fourth Dimension Regulate Drug Relapse

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• 作者：Patrick J. Mulholland¹ ; ² ; ^{mulholl@musc.edu" class="auth_mail" title="E-mail the corresponding author} ; L. Judson Chandler¹ ; ² ; Peter W. Kalivas¹ ; ^{kalivas@musc.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：drug addiction ; synaptic plasticity ; tetrapartite synapses ; extracellular matrix
• 刊名：Trends in Neurosciences
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：39
• 期：7
• 页码：472-485
• 全文大小：3059 K

文摘

Despite the enormous societal burden of alcohol and drug addiction and abundant research describing drug-induced maladaptive synaptic plasticity, there are few effective strategies for treating substance use disorders. Recent awareness that synaptic plasticity involves astroglia and the extracellular matrix is revealing new possibilities for understanding and treating addiction. We first review constitutive corticostriatal adaptations that are elicited by and shared between all abused drugs from the perspective of tetrapartite synapses, and integrate recent discoveries regarding cell type-specificity in striatal neurons. Next, we describe recent discoveries that drug-seeking is associated with transient synaptic plasticity that requires all four synaptic elements and is shared across drug classes. Finally, we prognosticate how considering tetrapartite synapses can provide new treatment strategies for addiction.