Cross-generational THC exposure alters the developmental sensitivity of ventral and dorsal striatal gene expression in male and female offspring

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• 作者：Henrietta Szutorisz^a ; Gabor Egervá ; ri^a ; ^b ; James Sperry^a ; Jenna M. Carter^a ; Yasmin L. Hurd^a ; ^b ; ^{yasmin.hurd@mssm.edu}
• 关键词：Marijuana ; Cross-generational transmission ; Development ; Striatum ; Gender ; Synaptic plasticity
• 刊名：Neurotoxicology and Teratology
• 出版年：2016
• 出版时间：November-December 2016
• 年：2016
• 卷：58
• 期：Complete
• 页码：107-114
• 全文大小：2107 K
• 卷排序：58

文摘

Parental germline THC exposure dysregulates striatal genes related to synaptic plasticity in both F1 males and females. Gene expression changes show a developmental shift between adolescence and adulthood. Females have stronger alterations in mRNA co-expression patterns for synaptic plasticity genes in the dorsal striatum. Females with parental germline THC exposure exhibit decreased novelty seeking behavior, which is not observed in males.