GLT-1: The elusive presynaptic glutamate transporter
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- 作者：Theresa S. Rimmelea ; Paul A. Rosenberga ; b ; paul.rosenberg@childrens.harvard.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Glutamate homeostasis ; Synaptic plasticity ; Synaptogenesis ; Aging ; Neurodegeneration ; Glutamate-glutamine cycle ; Schizophrenia ; Addiction ; Metabolism ; Mitochondria
- 刊名：Neurochemistry International
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：98
- 期：Complete
- 页码：19-28
- 全文大小：2427 K
文摘
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Review of 40 year history of effort to characterize presynaptic glutamate transport.
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GLT-1a is the glutamate transporter in excitatory terminals.
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A conditional GLT-1 knockout confirms its presence and function in axon terminals.
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Mismatch between neuronal and astrocytic GLT-1 uptake and protein expression.