Activation of Fas death receptor pathway and Bid in hepatocytes is involved in saikosaponin D induction of hepatotoxicity
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- 作者：Feng Zhanga ; b ; Li Chena ; Huanhuan Jina ; Jiangjuan Shaoc ; Li Wua ; Yin Lua ; b ; Shizhong Zhenga ; b ; nytws@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：DILI ; drug-induced liver injury ; DMEM ; Dulbecco's modified Eagle medium ; DMSO ; dimethylsulfoxide ; ERK ; extracellular signal-regulated kinase ; FBS ; fetal bovine serum ; HE ; hematoxylin&ndash ; eosin ; LDH ; lactate dehydrogenase ; PDGF-βR ; platelet-derived growth factor-β receptor ; PI3K ; phosphoinositide 3-kinase ; SSD ; saikosaponin D ; STAT3 ; signal transducers and activators of transcription 3 ; tBid ; C-terminal truncated Bid
- 刊名：Environmental Toxicology and Pharmacology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：41
- 期：Complete
- 页码：8-13
- 全文大小：1292 K
文摘
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SSD induced mitochondrial apoptosis in hepatocytes.
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SSD activates Fas-mediated death receptor signaling in hepatocytes.
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SSD activates Bid and stimulates cytochrome c release in hepatocytes.
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SSD does not affect some pathways regulating cell fate in hepatocytes.
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SSD induces hepatocyte apoptotic death in mice.