The neuroplasticity following cerebral ischemia is ameliorated by BMSCs transplant. The mechanism may be associated with the expressional change of phosphorylated collapsin response mediator protein 2 (p-CRMP2). The secretion of neurotrophins and the activation of signaling pathways by BMSCs may affect the expression of p-CRMP2. BMSCs treatment could promote neuroplasticity impared by brain ischemic injury.