Secretome profiling of apheresis platelet supernatants during routine storage via antibody-based microarray
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文摘

Platelet extracellular vesicle formation correlates with calcium consumption during storage.

Platelet extracellular vesicle formation correlates with decreased platelet function of expired platelet concentrates.

Changing factors in the secretome form two clusters using STRING database.

Cluster 1 is associated with coagulation and haemostasis and cluster 2 with RNA binding.

Most changing proteins were found to be associated with exosomes.

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