• 作者：O. Garraud^a ; ^b ; ^{olivier.garraud@efs.sante.fr} ; F. Cognasse^a ; ^b ; H. Hamzeh-Cognasse^b ; S. Laradi^a ; ^b ; B. Pozzetto^b ; J.-Y. Muller^c
• 关键词：Transfusion ; Produits sanguins labiles ; Inflammation ; Hé ; movigilance ; Cytokines ; Incidents transfusionnels
• 刊名：Transfusion Clinique et Biologique
• 出版年：2013
• 出版时间：May, 2013
• 年：2013
• 卷：20
• 期：2
• 页码：231-238
• 全文大小：1077 K

Transfusion of labile blood products (LBPs) generates occasional inflammatory?: type, hazards; for a large part of these, no antigen/antibody conflict is thus, detected. Residual leucocytes used to account for a large part of such incidents?- rarely accidents. Since, however, the systematic leukoreduction of LBPs, leucocytes are the less and less incriminated in adverse events. Platelets themselves proved capable of secreting copious amounts of inflammatory mediators, even in the absence of any deliberated stimulation. Meanwhile, even though exceptionally, inflammation can be observed after red blood cell transfusion. It has been noticed that the collection mode of cellular compounds, as well as the preparation and storage conditions are capable of inflicting lesions to the cell membranes and to activate those cells, and thus promoting inflammatory responses. Storage lesions as well as ageing of the stored cells alongside with cell apoplosis contribute to inflammatory responses. This present ¡®State of the Art¡¯ paper aims at encompassing the primary and secondary components of the LBPs, along with the various types of molecules displaying pro-inflammatory properties that can be encountered in transfusion. A better knowledge of causes of inflammatory transfusion-linked hazards is indeed instrumental to the implementation of safety measures aimed at reducing or suppressing these unwanted effects.