To Die or Not to Die: Sema3E Rules the Game

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• 作者：Luca Tamagnone ; Michael Rehman
• 刊名：Cancer Cell
• 出版年：11 November, 2013
• 年：2013
• 卷：24
• 期：5
• 页码：564-566
• 全文大小：477 K

文摘

Sema3E, a ligand for PlexinD1, controls angiogenesis and promotes cancer invasion and metastasis. In this issue of Cancer Cell, Luchino and colleagues report that Sema3E also ensures breast cancer cell viability by聽blocking a previously unknown proapoptotic signaling cascade elicited by unliganded PlexinD1, thus behaving as a 鈥渄ependence receptor.鈥?/div>