Pa2G4 is a novel Six1 co-factor that is required for neural crest and otic development

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• 作者：Karen M. Neilson^a ; Genevieve Abbruzzesse^b ; ¹ ; Kristy Kenyon^c ; Vanessa Bartolo^b ; Patrick Krohn^a ; Dominique Alfandari^b ; Sally A. Moody^a ; ^{samoody@gwu.edu}
• 关键词：Branchiootorenal ; SIX1 ; Eya1 ; Ebp1 ; Plfap
• 刊名：Developmental Biology
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：421
• 期：2
• 页码：171-182
• 全文大小：1283 K
• 卷排序：421

文摘

Pa2G4 binds to Six1 and interferes with the Six1-Eya1 complex. Pa2G4 knock-down reduces neural border, neural crest and cranial placode genes. Increasing Pa2G4 expands neural crest genes mostly at the expense of placode genes. Both alterations cause later defects in branchial arch and otocyst gene expression. We suggest pa2g4 as a candidate gene for Branchiootorenal Spectrum disorder.