Evaluation of cytokine responses against novel Mtb antigens as diagnostic markers for TB disease
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- 作者：Dolapo O. Awoniyia ; Andrea Teucherta ; Jayne S. Sutherlandb ; Harriet Mayanja-Kizzac ; Rawleigh Howed ; Adane Mihretd ; Andre G. Loxtona ; Jacob Sheehamae ; Desta Kassaf ; Amelia C. Cramping ; h ; Hazel M. Dockrellh ; Martin Kiddi ; Ida Rosenkrandsj ; Annemieke Gelukk ; Tom H.M. Ottenhoffk ; P.L.A.M. Corstjensl ; Novel N. Chegoua ; Gerhard Walzla ; gwalzl@sun.ac.za" class="auth_mail" title="E-mail the corresponding author ; the AE-TBC ConsortiumGerhard Walzlm ; Novel N. Chegoum ; Magdalena Krielm ; Gian van der Spuym ; Andre G. Loxtonm ; Kim Stanleym ; Stephanus Malherbem ; Shirley Mcandam ; Belinda Krielm ; Khutso G. Phalanem ; Paulin Essonem ; Jayne S. Sutherlandn ; Olumuyiwa Owolabin ; Abdou Sillahn ; Joseph Mendyn ; Awa Gindehn ; Simon Donkorn ; Toyin Togunn ; Martin Otan ; Amelia C. Crampino ; Felanji Simukondao ; Alemayehu Amberbiro ; Femia Chilongoo ; Rein Houbeno ; Desta Kassap ; Atsbeha Gebrezgeabherp ; Getnet Mesfinp ; Yohannes Belayp ; Gebremedhin Gebremichaelp ; Yodit Alemayehup ; Marieta van der Vyverq ; Faustina N. Amutenyaq ; Josefina N. Nelongoq ; Lidia Monyeq ; Jacob A. Sheehamaq ; Scholastica Iipingeq ; Harriet Mayanja-Kizzar ; Ann Ritah Namugangar ; Grace Muzanyer ; Mary Nserekor ; Pierre Petersr ; Rawleigh Howes ; Adane Mihrets ; Yonas Bekeles ; Bamlak Tessemas ; Lawrence Yamuahs ; Tom H.M. Ottenhofft ; Annemieke Gelukt ; Kees Frankent ; Paul L.A.M. Corstjenst ; Elisa M. Tjon Kon Fatt ; Claudia J. de Doodt ; Jolien J. van der Ploeg-van Schipt ; Ida Rosenkrandsu ; Claus Aagaardu ; Stefan H.E. Kaufmannv ; Maria M. Esterhuysev ; Jacqueline M. Cliffw ; Hazel M. Dockrellw
- 关键词：Biosignature ; Host markers ; Antigen
- 刊名：Journal of Infection
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：73
- 期：3
- 页码：219-230
- 全文大小：1238 K
文摘
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We evaluated the utility of host markers elicited after overnight stimulation of whole blood with Mtb antigens.
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We identified a six analyte biosignature that showed promise in the diagnosis of active TB.
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The identified host markers may be useful in improving the sensitivity of immunodiagnostic assays for TB disease.
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Stimulation with Mtb antigens may not add value to unstimulated marker levels in the diagnosis of TB disease.