Purple sweet potato color ameliorates kidney damage via inhibiting oxidative stress mediated NLRP3 inflammasome activation in high fat diet mice
详细信息 查看全文
- 作者：Qun Shana ; shanp@jsnu.edu.cn" class="auth_mail ; Yuanlin Zhenga ; ylzheng@jsnu.edu.cn" class="auth_mail ; ylzheng@xznu.edu.cn" class="auth_mail ; Jun Lua ; lu-jun75@163.com" class="auth_mail ; Zifeng Zhanga ; zhangzifengsuper@jsnu.edu.cn" class="auth_mail ; Dongmei Wua ; wdm8610@jsnu.edu.cn" class="auth_mail ; Shaohua Fana ; fshfly@126.com" class="auth_mail ; Bin Hua ; hubin@jsnu.edu.cn" class="auth_mail ; Xiangjun Caia ; caixiangjun1@163.com" class="auth_mail ; Hao Caib ; caihao9107@163.cm" class="auth_mail ; Peilong Liub ; lpl221700@163.com" class="auth_mail ; Fan Liub ; liufan_001@hotmail.com" class="auth_mail
- 关键词：ACR ; urine albumin/creatinine ratio ; AGEs ; advanced glycation end products ; ASC ; apoptosis associated speck-like protein containing a CARD ; Col IV ; Collagen IV ; COX-2 ; cyclooxygenase-2 ; HFD ; high fat diet ; IL-1尾 ; interleukin-1尾 ; iNOS ; induce nitric oxide synthase ; I魏B伪 ; I kappa B 伪 ; IKK尾 ; I kappa B kinase 尾 ; PSPC ; purple sweet potato color ; NF-魏B ; nuclear factor kappa beta ; NLRP3 ; NOD-like receptor 3 ; PAI-1 ; plasminogen activator inhibitor-1 ; ROS ; reactive oxygen species ; RAGE ; the receptor of a
- 刊名：Food and Chemical Toxicology
- 出版年：July 2014
- 年：2014
- 卷：69
- 期：Complete
- 页码：339-346
- 全文大小：1990 K
文摘
- •
PSPC ameliorates obesity, glucose intolerance and insulin resistance induced by HFD.
- •
PSPC reduces urine albumin and kidney tissue damage in HFD-treated mice.
- •
PSPC attenuates oxidative stress in the kidney of HFD-treated mice.
- •
PSPC inhibits the activation of kidney IKK尾/NF-魏B signaling in HFD-treated mice.
- •
PSPC reduces the activation of NLRP3 inflammasome in HFD-treated mice.
- •
PSPC decreases the protein expression of kidney RAGE and TXNIP in HFD-treated mice.