In situ forming pluronic® F127/chitosan hydrogel limits metronidazole transmucosal absorption

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• 作者：Sophia Malli^a ; ^b ; Christian Bories^b ; Bé ; né ; dicte Pradines^b ; Philippe M. Loiseau^b ; Gilles Ponchel^a ; Kawthar Bouchemal^c ; ^{kawthar.bouchemal@u-psud.fr}
• 关键词：Pluronic&reg ; F127 ; Chitosan ; Mucosal passage ; Thermosensitive ; Hydrogel ; Trichomonas vaginalis
• 刊名：European Journal of Pharmaceutics and Biopharmaceutics
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：112
• 期：Complete
• 页码：143-147
• 全文大小：327 K
• 卷排序：112

文摘

The objective of this work is to design topically-applied thermosensitive and mucoadhesive hydrogel containing metronidazole (MTZ) for the treatment of Trichomonas vaginalis infections. Hydrogel composed of pluronic® F127 (20 wt%), chitosan (1 wt%) and metronidazole MTZ (0.7 wt%) mixture showed its ability to decrease by a factor 4 MTZ flux and apparent permeability absorption through vaginal mucosa. The impact of hydrogel on transmucosal penetration of MTZ was evaluated ex vivo on excised porcine vaginal mucosa mounted on Franz diffusion cell. The anti-T. vaginalis activity of MTZ formulated into F127/chitosan hydrogel was preserved since the viability curve evaluated in vitro was similar to MTZ solution.