Human Cytotoxic T Lymphocytes Form Dysfunctional Immune Synapses with B Cells Characterized by Non-Polarized Lytic Granule Release
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- 作者：Anna Kabanova1 ; anna.kabanova@unisi.it" class="auth_mail" title="E-mail the corresponding author ; Francesca Sanseviero1 ; Candi Veronica2 ; Alessandra Gamberucci3 ; Alessandro Gozzetti2 ; Giuseppe Campoccia4 ; Monica Bocchia2 ; Cosima Tatiana Baldari1
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：5 April 2016
- 年：2016
- 卷：15
- 期：1
- 页码：9-18
- 全文大小：3074 K
文摘
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B cells instruct cytotoxic T cells (CTL) to degranulate in a non-polarized fashion
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B cells resist killing by freshly isolated CTLs but not by in vitro expanded blasts
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Non-lytic degranulation is associated with defective activation of LAT
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Granule dispersion and exocytosis are mediated by the GTPases Arl8 and Rab27a