LAT1 is the transport competent unit of the LAT1/CD98 heterodimeric amino acid transporter
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- 作者：Lara Napolitano1 ; Mariafrancesca Scalise1 ; Michele Galluccio ; Lorena Pochini ; Leticia Maria Albanese ; Cesare Indiveri ; cesare.indiveri@unical.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：CATs ; cationic amino acid transporters ; LATs ; light subunits of amino acid transporters ; CD98 ; cluster of differentiation 98 ; BBB ; blood brain barrier ; BCH ; 2-amino-2-norbornanecarboxylic acid ; C12E8 ; octaethylene glycol monododecyl ether ; DTE ; dithioerythritol ; TX-100 ; Triton X-100
- 刊名：International Journal of Biochemistry and Cell Biology
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：67
- 期：Complete
- 页码：25-33
- 全文大小：1796 K
文摘
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[3H]His transport was measured in intact SiHa and in proteoliposomes.
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Cleavage of disulfide between CD98 and LAT1 did not modify transport properties.
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Transport in proteoliposomes reconstituted with the sole hLAT1 confirmed data.
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Therefore, LAT1 is the sole transport competent unit of the heterodimer.