刊名:Biochemical and Biophysical Research Communications
出版年:2017
出版时间:29 January 2017
年:2017
卷:483
期:1
页码:318-324
全文大小:1159 K
卷排序:483
文摘
Up-regulation of miR-217 is validated in podocytes under HG condition. miR-217 repression antagonizes HG-triggered podocytes injury and insulin resistance. Inhibition of miR-217 restores the defective autophagy in HG-stimulated podocytes. PTEN is a direct target of miR-217 in podocytes. Blocking PTEN and autophagy involves in miR-217-mediated podocyte dysfunction upon HG.