The C-terminal region of Reelin is necessary for proper positioning of a subset of Purkinje cells in the postnatal cerebellum
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- 作者：Kota Nakamura ; Mako Beppu ; Kaori Sakai ; Hayata Yagyu ; Saori Matsumaru ; Takao Kohno ; Mitsuharu Hattori ; mhattori@phar.nagoya-cu.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：AP ; alkaline-phosphatase ; ApoER2 ; apolipoprotein E receptor 2 ; CTR ; C-terminal region ; EDTA ; ethylenediaminetetraacetic acid ; EGL ; external granule layer ; HEPES ; 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid ; IP3R1 ; inositol 1 ; 4 ; 5-trisphosphate receptor type 1 ; P ; postnatal day ; PBS ; phosphate-buffered saline ; PC ; Purkinje cells ; RR ; Reelin repeats ; SDS&ndash ; PAGE ; sodium dodecyl sulfate&ndash ; polyacrylamide gel electrophoresis ; VLDLR ; very low-density lipoprotein receptor ; WT ; wild-type ; Δ
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：12 November 2016
- 年：2016
- 卷：336
- 期：Complete
- 页码：20-29
- 全文大小：4365 K
文摘
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Tens of Purkinje cells are located ectopically in mice that lack the Reelin C-terminal region.
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Ectopic PCs are selectively found in the lobule VI/VII and often form clusters.
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Insufficient cell-autonomous Reelin signaling is likely to cause the ectopicity.
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Reelin protein with intact CTR binds preferentially to Purkinje cells.