Effect of substituting IPV for tOPV on immunity to poliovirus in Bangladeshi infants: An open-label randomized controlled trial
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- 作者：Josyf C. Mychaleckyja ; Rashidul Haqueb ; Marya Carmollic ; Dadong Zhangd ; E. Ross Colgatec ; Uma Nayakd ; Mami Taniuchie ; Dorothy Dicksonc ; William C. Weldonf ; M. Steven Oberstef ; K. Zamanb ; Eric R. Houpte ; Masud Alamb ; Beth D. Kirkpatrickg ; William A. Petri Jr.e ; wap3g@virginia.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Inactivated poliovirus vaccine ; Oral poliovirus vaccine ; Shedding ; Serum neutralizing antibody ; Intestinal immunity ; Poliomyelitis
- 刊名：Vaccine
- 出版年：2016
- 出版时间：12 January 2016
- 年：2016
- 卷：34
- 期：3
- 页码：358-366
- 全文大小：805 K
文摘
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We tested two poliovirus vaccination regimens substituting IPV for the 4th EPI tOPV dose.
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Neither regimen gave superior intestinal mucosal immunity measured by 1-year poliovirus shedding.
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The two regimens were equivalent within a 95%CI margin of prevalence of shedding of −10% to +4%.
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20">Results for shedding analyses stratified by poliovirus type were similar.
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25">IPV regimen strongly enhanced humoral immunity with higher sero-prevalence and -conversion.