Effect of Ca⁺² ion on the release of diltiazem hydrochloride from matrix tablets of carboxymethyl xanthan gum graft polyacrylamide

详细信息    查看全文

• 作者：Hemant R. Badwaik^a ; Kalyani Sakure^a ; Kartik T. Nakhate^a ; Pranita Kashayap^b ; Hemant Dhongade^b ; Amit Alexander¹ ; ^a ; ^{itsmeamitalex@gmail.com} ; Ajazuddin^a ; Dulal Krishna Tripathi^a
• 关键词：Carboxymethyl xanthan gum-graft-polyacrylamide ; Cross-linker ; Wet granulation
• 刊名：International Journal of Biological Macromolecules
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：94
• 期：part_PA
• 页码：691-697
• 全文大小：981 K
• 卷排序：94

文摘

The effect of Ca2+ ion on CMXG-g-PAAm for the drug release was investigated. Tablets prepared by wet granulation control the drug release upto 8 h. The drug transport mechanism is diffusion and erosion from CMXG-g-PAAm matrix.