Diverse antigenic site targeting of influenza hemagglutinin in the murine antibody recall response to A(H1N1)pdm09 virus
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- 作者：Jason R. Wilson1 ; Zhu Guo1 ; Wen-Pin Tzeng ; Rebecca J. Garten ; Xu Xiyan ; Elisabeth G. Blanchard ; Kristy Blanchfield ; James Stevens ; Jacqueline M. Katz ; Ian A. York ; ite1@cdc.gov" class="auth_mail" title="E-mail the corresponding author
- 关键词：Influenza ; Monoclonal antibody ; Epitope mapping ; Antigenic site ; Virus neutralization ; Antigenic drift ; A/H1N1/pdm09
- 刊名：Virology
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：485
- 期：Complete
- 页码：252-262
- 全文大小：2100 K
文摘
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Epitope mapping nine recombinant monoclonal antibodies targeting the HA of A(H1N1)pdm09 identified at least seven distinct footprints on the HA1 domain.
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Naturally-occurring changes in the HA of virus isolates can reduce mAb binding without causing changes in recognition by polyclonal antiserum.
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rmAbs targeting antigenic site Sa were cross-reactivity with the HA of A/South Carolina/1/18.