Synthesis of the polycyclic core of vincorine via cascade reactions

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• 作者：Zhi-Wei Zhang ; Jiong Yang
• 关键词：Polycycle ; Vincorine ; Pyrroloindoline ; Cascade reaction ; Michael&ndash ; Mannich
• 刊名：Tetrahedron Letters
• 出版年：15 January, 2014
• 年：2014
• 卷：55
• 期：3
• 页码：761-763
• 全文大小：496 K

文摘

We developed a six-step synthesis of the polycyclic core of vincorine using two cascades of reactions. A cascade of Michael-Mannich reactions was employed for one-pot preparation of a polycyclic intermediate, which was transformed into the desired polycyclic pyrroloindoline ring system using a cascade of methanolysis-N-imine cyclization reactions.