The Risk for New-Onset Diabetes Mellitus after Kidney Transplantation in Patients with Autosomal Dominant Polycystic Kidney Disease: A Systematic Review and Meta-Analysis

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• 作者：Wisit Cheungpasitporn ; MD^a ; ¹ ; ^{wcheungpasitporn@gmail.com} ; Charat Thongprayoon ; MD^a ; ¹ ; Priya Vijayvargiya ; MD^b ; Pimjai Anthanont ; MD^c ; ^d ; Stephen B. Erickson ; MD^a
• 关键词：autosomal dominant polycystic kidney disease (ADPKD) ; diabetes ; graft ; kidney ; meta-analysis ; new-onset diabetes ; polycystic kidney ; polycystic kidney diseases ; transplantation
• 刊名：Canadian Journal of Diabetes
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：40
• 期：6
• 页码：521-528
• 全文大小：1046 K
• 卷排序：40

文摘

New-onset diabetes after kidney transplantation (NODAT) is associated with both renal allograft failure and increased rates of mortality. The objective of this meta-analysis was to evaluate the risk for NODAT in patients with autosomal dominant polycystic kidney disease (ADPKD).MethodsA literature search was performed using MEDLINE, EMBASE and Cochrane Database of Systematic Reviews from inception through July 2015. Studies that reported relative risks, odd ratios or hazard ratios comparing the risk for NODAT in patients with ADPKD were included. Pooled risk ratios (RRs) and 95% confidence intervals (CIs) were calculated using a random-effect, generic inverse variance method.ResultsIncluded in the analysis were 12 cohort studies, which comprised 1379 patients with ADPKD of a total of 9849 patients who had undergone kidney transplants. The pooled RRs of NODAT in patients with ADPKD were 1.92 (95% CI, 1.36 to 2.70). When meta-analysis was limited only to studies with confounder-adjusted analysis, the pooled RRs for NODAT were 1.98 (95% CI, 1.33 to 2.94). However, the association between NODAT requiring insulin treatment was insignificant, with pooled RRs of 1.57 (95% CI, 0.75 to 3.27).ConclusionsOur meta-analysis demonstrates a significant association between ADPKD and NODAT in recipients of kidney transplants. The findings of this study may impact clinical management and follow up for patients with ADPKD after kidney transplantation.