A model of ovulatory regulation examining the effects of insulin-mediated testosterone production on ovulatory function

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• 作者：Erica J. Graham^a ; ^{ejgraham@brynmawr.edu} ; James F. Selgrade^b
• 关键词：Polycystic ovary syndrome ; Steroidogenesis
• 刊名：Journal of Theoretical Biology
• 出版年：2017
• 出版时间：7 March 2017
• 年：2017
• 卷：416
• 期：Complete
• 页码：149-160
• 全文大小：3039 K
• 卷排序：416

文摘

We develop a model of the menstrual cycle with ovarian steroidogenesis. Excessive insulin-mediated testosterone production promotes ovulatory dysfunction. Premature luteinization exacerbates ovulatory dysfunction. Provides insight into distinct phenotypes of polycystic ovary syndrome.